Advances in the laboratory diagnosis of tuberculosis

Despite the advances made in past 30 years laboratory diagnosis of tuberculosis (TB), only a small portion overall world population has benefitted. The World Health Organization (WHO) recommended use nucleic acid amplification tests (NAAT) to detect TB instead smear microscopy, since they can with greater precision, particularly patients paucibacillary disease and individuals living HIV. A broad range molecular detection are currently being developed evaluated, some for reference laboratories others peripheral medical care settings point-of-care. There been surge designed, manufactured, implemented countries high load, specifically meant locations that close patient. In terms drug susceptibility testing, NAAT next-generation sequencing may provide faster results than traditional phenotype culture. Further, or quantify cytokines released inflammatory process latent infection (LTBI), such as Interferon-Gamma Release Assay (IGRA), IL-6 other cytokines, depend, tuberculin skin (TST), on prevalence tested population. We herein review recent resistance anti-TB drugs.